Having had both in stock form, you can really feel the difference on the interstate, however, taking off not as much. the POTENTIAL for waking up the respective engines is much easier/less expensive with the V8. AND it sounds better very easily!
The V8 is a little heavier, but swap on an aluminum intake and you are about equal. Open the exhaust a little and play with the carb/install a 4 bbl and you are having fun. You can find used intakes and appropriately sized 4 bbl's MUCH easier and more affordable for the v8.
That being said, I have had some great running 258's also with a Clifford Intake, header, performance cam and Holley 390 4 bbl. Even sounded good. If I had a 6 cyl car and just wanted a little pick me up in power I would work on the 6. (4.0 head and cam works well too!)
If I was looking for performance and hadn't bought a car yet and there were 2 choices of similar condition ,the V8 would be a good opening choice, imho.
The whole V8 in an Eagle thing is a LOT of work though!